Neomycin Sulfate for 99% Veterinary Drugs CAS: 1405-10-3

Neomycin Sulfate for 99% veterinary drugs  
Product Details
Basic Info.
 
Model NO.:1405-10-3
Varieties:Growth Promoting Medicine
Component:Botany
Type:The First Class
Pharmacodynamic Influential Factors:Animal Species
Storage Method:Moisture Proof
Form:Crystalline Solid
Color:White
CAS:1405-10-3
Mf:C23h48n6o17s
MW:712.72
Einecs:215-773-1
Export Markets:Global
 
Additional Info.
 
Trademark:Saichuang
Packing:Disguise
Standard:Qualified
Origin:China
HS Code:3001200090
Production Capacity:500 Tons/Month
 
Product Description
 
Neomycin Sulfate for 99% veterinary drugs

Neomycin sulfate
CAS: 1405-10-3
MF: C23H48N6O17S
MW: 712.72
EINECS: 215-773-1
MP >187° C (DEC. )
Refractive index 56 ° (C=10, H2O)
Storage temp. 2-8° C
Solubility H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8° C. Stable at 37° C for 5 days. 
Chemical Properties White powder. 
Usage antibacterial
Usage Neomycin is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. 

Detail description:

Neomycin Sulfate Tablets, USP, for oral administration, contain neomycin which is an antibiotic obtained from the metabolic products of the actinomycete Streptomyces fradiae. It has the following molecular formula: C23H46N6O. 2½ H2SO4 with a molecular weight of 614.67. 

Chemically, it is O-2, 6-diamino-2, 6-dideoxy-a -D- glucopyranosyl(1® 3)-O-b-D- ribofuranosyl-(1® 5) O-[2, 6-diamino-2, 6-dideoxy-a-D-glucopyranosyl-(1® 4)]-2-deoxy-D-streptamine. Neomycin B is identical except that the a- D- glucopyranosyl residue in the neobiosamine moiety is b-L-idopyranosyl. 

SYSTEMIC ABSORPTION OF NEOMYCIN OCCURS FOLLOWING ORAL ADMINISTRATION AND TOXIC REACTIONS MAY OCCUR. Patients treated with neomycin should be under close clinical observation because of the potential toxicity associated with their use. NEUROTOXICITY (INCLUDING OTOTOXICITY) AND NEPHROTOXICITY FOLLOWING THE ORAL USE OF NEOMYCIN SULFATE HAVE BEEN REPORTED, EVEN WHEN USED IN RECOMMENDED DOSES. THE POTENTIAL FOR NEPHROTOXICITY, PERMANENT BILATERAL AUDITORY OTOTOXICITY AND SOMETIMES VESTIBULAR TOXICITY IS PRESENT IN PATIENTS WITH NORMAL RENAL FUNCTION WHEN TREATED WITH HIGHER DOSES OF NEOMYCIN AND/OR FOR LONGER PERIODS THAN RECOMMENDED. Serial, vestibular and audiometric tests, as well as tests of renal function, should be performed (especially in highrisk patients). THE RISK OF NEPHROTOXICITY AND OTOTOXICITY IS GREATER IN PATIENTS WITH IMPAIRED RENAL FUNCTION. Ototoxicity is often delayed in onset and patients developing cochlear damage will not have symptoms during therapy to warn them of developing eighth nerve destruction and total or partial deafness may occur long after neomycin has been discontinued. 

Neuromuscular blockage and respiratory paralysis have been reported following the oral use of neomycin. The possibility of the occurrence of neuromuscular blockage and respiratory paralysis should be considered if neomycin is administered, especially to patients receiving anesthetics, neuromuscular blocking agents such as tubocurarine, succinylcholine, decamethonium, or in patients receiving massive transfusions of citrate anticoagulated blood. If blockage occurs, calcium salts may reverse these phenomena but mechanical respiratory assistance may be necessary. 

Concurrent and/or sequential systemic, oral or topical use of other aminoglycosides, including paromomycin and other potentially nephrotoxic and/or neurotoxic drugs such as bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin, should be avoided because the toxicity may be additive. 

Other factors which increase the risk of toxicity are advanced age and dehydration. 

The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. In addition, when administered intravenously, diuretics may enhance neomycin toxicity by altering the antibiotic concentration in serum and tissue. 

Specifications:

Item	Standard	Result
Characters	White to slightly yellow powder, odorless or practically so,	Conforms
Identification	A.Thin-layer chromatogram meets the requirements	Conforms
	B. Positive	Positive
	C. Positive	Positive
PH	5.0~7.5	6.5
Loss on drying	NMT 8.0%	5.8%
Potency	NLT 600µg/mg(dried basis)	706µg/mg(dried basis)
		665µg/mg(as is)