Chemical Information:| Product Name | |
| Molecular Formula | C22H24FN5O4 |
| Molecular Weight | 369.3696232 |
| Storage | Store at -20°C |
| Targets | VEGFR2 | Flk1 | FGFR1 | VEGFR1 |
| IC50 | 25 nM | 89 nM | 148 nM | 380 nM |
| Dosage | 90 mg/kg |
| Stability | 3 years - 20 ºC powder 6 months -80 ºC dissolved in a solvent |
| Solubility | Soluble in DMSO > 10 mM |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
Details:Synonyms:Bms 582664;Bms582664;Brivanib alaninate;L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester;Unii-U2Y5ofn795;(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester;Brivanib alaninate(BMS-582664);L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester
Description:Brivanib Alaninate (BMS-582664) BMS-540215 is a prodrug, an ATP competitive VEGFR2 inhibitor, IC50 of 25 nM.
Application:BMS-582664 inhibits VEGF and FGF-stimulated HUVECs proliferation, IC50 of 40 nM, respectively, and 276 nM. [1] BMS-582664 (2 μM) acting on the VEGF and bFGF stimulated SK-HEP1 cells and HepG-2 cells, significantly inhibited VEGFR-2, FGFR-1, ERK1 / 2 and Akt phosphorylation, and BMS-582664 alone in unstimulated cells, then the ERK1 / 2, Akt, VEGFR-2, and the level of phosphorylation of FGFR-1 has no effect. [2] BMS-582664 to inhibit CYP2C19, CYP3A4 (BFC) and CYP3A4 (BzRes), IC50 were 2.4 μM, 0.51 μM and 1.6 μM. BMS-582664 has a high solid state stability (only 0.3% in the desiccant during 12 weeks at 50 ° C degradation), while at pH 6.5 also has considerable liquid stability. [3]
Other Small Molecular API:| AZD9291 | 1421373-65-0 |
| E7080 | 417716-92-8 |
| Afatinib diMaleate | 439081-18-2 |
| XL184 S-MALATE | 1140909-48-3 |
| Crizotinib | 877399-52-5 |
| Axitinib | 319460-85-0 |
| WZ4002 | 1213269-23-8 |
| Vandetanib | 443913-73-3 |
| Sunitinib | 557795-19-4 |
| Regorafenib | 755037-03-7 |
| Imatinib | 152459-95-5 |
| Foretinib | 849217-64-7 |
| trametinib | 871700-17-3 |
| Tivozanib | 475108-18-0 |
| Pelitinib | 257933-82-7 |
| Cediranib | 288383-20-0 |
| Selumetinib | 606143-52-6 |
| Tozasertib | 639089-54-6 |
| CapMatinib | 1029712-80-8 |
| Amuvatinib | 850879-09-3 |
| Lestaurtinib | 111358-88-4 |
| Brivanib | 649735-46-6 |
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Biocar is a leading manufacturer and supplier of Anabolic/Androgenic Steroid Hormone Powders, Pharmaceutical raw materials, Pharmaceutical Intermediates after decades years of experience.
From Wuhan University, Wuhan Institute of Technology and huazhong university of science& technology, we set up a group of technical experts, optimize the steroid synthetic and green production process to ensure that Biocar production technology in a leading international Level. Biocar steroid products have certified by GMP and COS, sales network spread over the countries in Asia, Europe, North America, South America.
Wuhan Biocar Bio-Pharm Co., Ltd was founded in 2001, formerly known as Tongshan Pharmaceutical Factory Company, which is a national high-tech enterprises. In 2014, in the process of creating a National Industrial Base, the Board of Directors decided to move the headquarter to Wuhan Biomedical Park. At the same time, with the advantages of the park policy, we carry out production and research cooperation with Humanwell Healthcare Gruop Co., Ltd, officially changed its name to Biocar Bio-Pharm Co., Ltd.
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