Quick Detail:
Lidocaine
CAS: 137-58-6
Assay: 99%
MF: C14H23N2O58
MW: 235.3447
Reference Standard: BP2002/USP28
Character: White crystalline powder
Usage: It replaces procaine,being widely used in plastic and cosmetic operation in local infiltration anesthesia, the sodium channel inhibition of the nerve cell membrane to block nerve excitability and conduction.
Product Description:
Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.
Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.
Applications:
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action.
Epinephrine vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.[2] Lidocaine drops can be used on the eyes for short ophthalmic procedures.
Relative insensitivity to lidocaine is genetic. In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.
Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge
Lidocaine crosses the blood-brain and placental barriers, presumably by passive diffusion.
Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine. Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2, 6-dimethylaniline.
Lidocaine COA
Product name | Lidocaine | CAS No. | 137-58-6 |
| Items Tested | Specification | BP2007 | Result |
| Characters | White crystal powder with characteristic odor | White crystal powder with weak odor |
| Melting point | 66 - 70 | 66.6 - 68.5 |
| Appearance of solution | Clear and colorless | Conforms |
| Identification | B\C\D\E Comply with the requirement | Conforms |
| Water | < 0.5% | 0.3% |
| Sulphate | < 0. 1% | Conforms |
| Residue on Ignition | < 0.1% | 0.02% |
| Chloride | < 0. 0035% | 0.0025% |
| Heavy Metals | < 0.002% | 0.001% |
| Impurity | < 0.01% | Conforms |
| Assay (HPLC) | 99.0%-101.0% | 99.6% |
| Conclusion | Conforms BP2007 |
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Peptides | Specification |
| MGF | 2mg |
| PEG MGF | 2mg |
| CJC-1295 with DAC | 2mg |
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| PT-141 | 10mg |
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| GHRP-2 | 10mg |
| GHRP-6 | 5mg |
| GHRP-6 | 10mg |
| Ipamorelin | 2mg |
| Hexarelin | 2mg |
| Sermorelin | 2mg |
| Oxytocin | 2mg |
| TB500 | 2mg |
| Pentadecapeptide BPC 157 | 2mg |
| Triptorelin | 2mg |
| Tesamorelin | 2mg |
| Gonadorelin | 2mg |
| Gonadorelin | 10mg |
| DSIP | 2mg |
| Selank | 5mg
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-------------------------------- Additional Information -------------------------------
Place of origin : China
Brand : SMQ
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Minimum order quantity : 1 kg
Production capacity : 1000 Kilograms/Month
-------------------------------- Delivery Information ---------------------------------
Packing : Foil bag/tin or as your request
Payment : T/T, Western Union, MoneyGram
Port : Shanghai, Shenzhen, Hongkong
Shipment method : EMS, DHL, FeDex, UPS, etc
Leading time : Within 24 hours after payment
Delivery time : Within 6 business days after payment (door to door service)
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Shenzhen Simeiquan Biotechnology Co., Ltd. is a subsidiary company of Wuhan Yuancheng Group, which located in Shenzhen. We are a leading Chinese chemical supplier special in fine chemical, flavor, food additive, pharmaceutical intermediates and steroid raw powders. Our main products are Cinnamic acid, Chloramphenicol, Tranexamic acid, Oryzanol, Griseofulvin, Benzocaine, Lidocaine, Steroid raw powders etc. Our products are praised by customers from worldwide.
We advocate an enterprise idea that"Efficient innovation, integrity rigorous, friendship development, win-win cooperation. " On base of Survival by quality, Create profit by service, Building prestige by law and discipline, we have high sense of social responsibility and unique charming enterprise culture.
Since the establishment of the company, Simeiquan has employed many professionals with aptitude and possessed a team of marketing personnel with profound professional knowledge, excellent professional ability and rich experience. The company specialized in chemicals, pharmaceutical intermediate, flavor and fragrance, food additive etc, and has world-wide customers. It's perfect marketing network and Service Platform can sever the customers from 20 countries and distracts in domestic, Occident and southeast Asia timely. The company have gained the trust of the customers by it's wholehearted and professional service.
