EDTA-Ca-Na

Ethylenediaminetetraacetate, Disodium And Calcium Disodium SaltsExplanationThese compounds have been evaluated for acceptable daily intake by the Joint FAO WHO Expert Committee on Food Additives (see Annex 1, Ref.No.13) in 1965.The previously published monograph has been revised and is reproduced in its entirety below.BIOLOGICAL DATABIOCHEMICAL ASPECTS14C-labelled CaNa2EDTA, when fed to rats in doses of 50 mg kg bw, was absorbed only to an extent of 2 to 4%; 80 to 90% of the dose appeared in the faeces within 24 hours, and absorption was still apparent at 48 hours.At the low pH of the stomach the calcium chelate is dissociated with subsequent precipitation of the free acid and this is only slowly redissolved in the intestines (Foreman et al., 1953).Experiments in man also revealed poor absorption; only 2.5% of a 3 g dose given was excreted in the urine (Srbova & Teisinger, 1957).These authors also confirmed the dissociation of the calcium chelate in the stomach.When 200 mg CaNa2EDTA was introduced into the duodenum of rats the authors found an absorption rate of 6.5 to 26%.A dose of 1.5 mg of 14C-labelled CaNa2EDTA given in a gelatine capsule to normal healthy men was absorbed to an extent of 5% (Foreman & Trujillo, 1954).In feeding experiments, in rats receiving disodium EDTA at dietary levels of 0.5, 1.0 and 5.0%, the faeces contained 99.4, 98.2 and 97.5% of the excreted material (Yang, 1964).Similar experiments conducted also in rats gave essentially the same results.Thirty-two hours after a single dose of 95 mg disodium EDTA/rat, 93% was recovered from the colon.After doses of 47.5, 95.0 and 142.5 mg disodium EDTA the amount of EDTA recovered in the urine was directly proportional to the dose given, suggesting that EDTA was absorbed from the gastrointestinal tract by passive diffusion.The motility of the intestine was not affected by the compound (Chan, 1964).

EDTA-Ca-Na product, offered by A & Z Food Additives Co., Ltd.