Eltrombopag AZD4547
CAS Number: 277299-70-4
Name: 3H-Pyrazol-3-one, 2-(3, 4-dimethylphenyl)-1, 2-dihydro-5-methyl-
Superlist Name:
2-(3, 4-Dimethylphenyl)-1, 2-dihydro-5-methyl-3H-pyrazol-3-one
Formula: C12H14N2O
Synonyms:
1-(3, 4-dimethylphenyl)-3-methyl-1H-pyrazol-5-ol; STOCK6S-35344; ZINC09530926;
Molecular Weight: 202.25
Eltrombopag(rINN, codenamed SB-497115-GR) is a medication that has been developed for conditions that lead to thrombocytopenia (abnormally low platelet counts). It is a small molecule agonist of the c-mpl (TpoR) receptor, which is the physiological target of the hormone thrombopoietin. Eltrombopag was discovered as a result of research collaboration between GlaxoSmithKline and Ligand Pharmaceuticals. Designated an orphan drug in the USA and European Union, it is being manufactured and marketed by GlaxoSmithKline under the trade namePromactain the USA and will be marketed asRevoladein the EU. Eltrombopag was approved by the U. S. Food and Drug Administration on November 20, 2008. [1]Eltrombopag received FDA breakthrough treatment designation in February 2014 for patients with aplastic anemia for which immunosupression has not been successful. [2]It has been shown to produce a trilineage hematopoesis in some patients with aplastic anemia, resulting in increased platelet counts, along with red and white blood cell counts
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