CAS: 54-05-7
Alternate Name: (7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline
MF: C18H26ClN3
Purity: 99%
General Description:
Chloroquine is a 4-aminoquinoline drug used in the treatment or prevention of malaria.
Chloroquine was discovered in 1934 by Hans Andersag and coworkers at the Bayer laboratories, who named it "Resochin". It was ignored for a decade because it was considered too toxic for human use.
Chloroquine has a very high volume of distribution, as it diffuses into the body's adipose tissue. Chloroquine and relatedquinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times.
The lysosomotropic character of chloroquine is believed to account for much of its antimalarial activity; The drug concentrates in the acidic food vacuole of the parasite and interferes with essential processes. Its lysosomotropic properties further allow for its use for in vitro experiments pertaining to intracellular lipid related diseases, autophagy, and apoptosis.
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