Ketoprofen Injection 100mg/2ml, Ketoprofen for Injection

Ketoprofen Injection 

Specification: 100mg/2ml
Package: 5 ampoules/tray/box, 2 ampoules/tray/box, 10 ampoules/box

Indications:

It is used in adults (over 15 years of age) for the short-term treatment of Certain flare-ups of inflammatory rheumatism. 
Acute low back pain.
Acute pain related to irritation of a nerve, such as sciatica.
Certain Intense pain. 

CTD dossier coulbe available.


Ketoprofen - Clinical Pharmacology
Ketoprofen is a non-steroidal anti-inflammatory drug with analgesic and antipyretic properties.
The anti-inflammatory, analgesic and antipyretic properties of Ketoprofen have been demonstrated in classical animal and in vitro test systems. In anti-inflammatory models Ketoprofen has been shown to have inhibitory effects on prostaglandin and leukotriene synthesis, to have antibradykinin activity, as well as to have lysosomal membrane-stabilizing action. However, its mode of action, like that of other non-steroidal anti-inflammatory drugs, is not fully understood.

Pharmacodynamics
Ketoprofen is a racemate with only the S enantiomer possessing pharmacological activity. The enantiomers have similar concentration time curves and do not appear to interact with one another.
An analgesic effect-concentration relationship for Ketoprofen was established in an oral surgery pain study with immediate-release Ketoprofen capsules. The effect-site rate constant (ke0) was estimated to be 0.9 hour-1 (95% confidence limits: 0 to 2.1), and the concentration (Ce50) of Ketoprofen that produced one-half the maximum PID (pain intensity difference) was 0.3 mcg/mL (95% confidence limits: 0.1 to 0.5). Thirty-three (33) to 68% of patients had an onset of action (as measured by reporting some pain relief) within 30 minutes following a single oral dose in postoperative pain and dysmenorrhea studies. Pain relief (as measured by remedication) persisted for up to 6 hours in 26 to 72% of patients in these studies.