Product Specifications
Product Description
Name: Metronidazole Injection
Structural formula: C6H9N3O3
Description the product is colorless or almost colorless pellucid liquid.
Pharmacology and toxicity
Potent Anaerobicidal Nitro -imidazole derivative. The exact mechanism of action of metronidazole is unknown. At physiologic pH, metronidazole is un-ionized and taken up readily by anaerobic organisms. The drug then undergoes intracellular chemical reduction via mechanisms unique to anaerobes. Reduced metronidazole interacts with DNA and inhibits nucleic acid synthesis, leading to cell death. Metronidazole is equally effective against dividing and nondividing cells.
Pharmacokinetics
The peak value is observed 20mins after administering by intravenous drip and binding rate with protein <5%. After absorption Metronidazole distributes widely in all kinds of tissues and body liquids, and pass easily blood brain barrier to the tissues such as saliva, placenta, bile, latex, ammiotic fluid, semen, urine, purulence, cerebrospinal fluid and etc. It is reported that the concentration in placenta, latex, bile is similar with that in plasma.
For the healthy people the concentration of Metronidazole in the cerebrospinal fluid is about 43% of that in the plasma, and the effective concentration can remain 12hours. 60~80% of the preparation is excreted via kidney, about 20% of Metronidazole is excreted unchanged in the urine, the other is excreted in the urine as the products of metabolism (25%- glucuronicacid combo, 14%-other kinds of products of metabolism). 10% of Metronidazole is excreted in the dejection, and 14% is excreted from skin.
Disease treated Metronidazole is mainly used in the treatment of anaerobe bacterial infection.
Administration and dosage By drip phleboclysis.
1. Doses for the adult In the treatment of anaerobic bacteria infections, administer by intravenous drip according to 1g/70kg for the first time, and calculate the does according to 7.5mg/kg during the course of treatment, and interval time is 6~8hours.
2. Doses for the children In the treatment of anaerobic bacteria infection, the doses are similar with that of the adult.
Side-effect 15~30% of the cases were reported side-effect, and adverse reactions frequently associated with Metronidazole include: Digestive tract reaction such as nausea, vomiting, and diarrhea stomach pain or cramps, anorexia; Symptoms of nerve system include headache and swirl; Abnormal sensation, numb limbs and tense tendons, ataxia, and multiple neuritis occasionally happen; Over high dose can cause convulsion. Few cases have the symptoms such as urticaria, moisst, pruritus, cystitis, dysuresia, change in taste sensation and decreased white cell. But the abovementioned symptoms are all reversible and recover after the administration.
Contraindication
Forbid to use the medicine for the patients with the diseases in central nervous system and flood.
Indication for women in pregnant and suckle
Forbid to use this medicine for women in pregnant and suckle.
Substance interactions
Metronidazole may increase the effects of Warfarin anticoagulants.
Overdose High dose may cause convulsion.
Specifications 100ml: 500mg
Storage instructions Light-resistant and store in well-closed containers.
Package Packed in plastic bottle
Validity Two years
Welcome to our company, we kindly hope establish win-win relationship with you. Not hesitate to contact with us.
Shijiazhuang No. 4 Pharmaceutical Co., Ltd. is established in 1948, specializing in the manufacture of large volume Intravenous Infusions.
For our main product of large volume I. V solution, there are 11 GMP approved production lines with the dosage of 1000ml/500ml/250ml/100ml/50ml, etc. At present, the annual capacity is more than 400 million bottles with 250 million glass bottles, 100 million PP (Polypropylene) plastic bottles and 50 million non-PVC plastic bags. Over 100 kind of products are produced in our company with BP/USP/CP standard. Some of them are as follows,
1.5% or 10% Glucose Infusion 100ml, 250ml, 500ml, 1000ml BP/USP/CP
2.0.9% Sodium Chloride Infusion 100ml, 250ml, 500ml, 1000ml BP/USP/CP
3. Glucose Infusion and Sodium Chloride Infusion 100ml, 250ml, 500ml, 1000ml BP/USP/CP
4. Sodium Ringer Lactate Infusion 500ml BP/USP/CP
5. Metronidazole Infusion 100ml: 500mg BP/USP/CP
6. Ciprofloxacin Lactate Infusion 100ml: 200mg BP/USP/CP
7. Fluconazole Infusion 100ml: 200mg BP/USP/CP
8. Ofloxacin Infusion 100ml: 200mg BP/USP/CP
9. Levofloxacin Lactate Infusion 100ml: 200mg BP/USP/CP
10. Mannitol Infusion 250ml: 50g BP/CP
11. Compound Amino Acid Infusion(3AA, 9AA, 15AA, 17AA, 18AA) 250ml 500ml
Our company introduces the most advanced auto-control equipments imported from Germany, Italy, Japan, Korea and so on. They are automatic control water system, automatic bottle-making machine, automatic control of washing-filling-sealing line, automatic sterilization system, automatic leak detection control system, automatic packing line, automatic distribution center.
Meanwhile, our company undertake the social responsibilities,
First, Environmental Protection. We insist on the path of environmental protection. The whole producing process is in an clear and "green" environments. The development is scientific and always takes the environments protection. There is enough green belt in our factory to affect our factory environment.
Second, Tax. The sale volume in 2005 is more than 0.27 billion and the benefit tax is exceed 0.1 billion.
Thank you for your interest in our company, we are looking forward to your quick reply.
If your have any questions, feel free to inform me.
