This drug mainly contains ozagrel, with a chemical name of (E)—3—(imidazolethyl—1—methyl)sodium acid cinnamon.
Molecular Structure: C13H11N2 Na O2
Molecular weight: 250.23
DESCRIPTION:
KADENIN is white or whitish lyophilized cake.
INDICATIONS: Used for the treatment of acute thrombotic cerebral infarction or disturbance on motor functions.
ADMINISTRATION AND DOSAGE:
For adult: 80mg, twice a day, solute in 500ml normal saline or 5% glucose solution, intravenous infusion, treatment duration is 2 weeks.
ADVERSE EFFECTS:
Blood: Because of bleeding tendency, careful observation is needed. Stop the administration once such abnormal symptom appears
Liver and kidney: Occasional increase of GOT, GPT, BUN
Digestive system: Occasional nausea, vomiting, diarrhea, anorexia, abdominal distention.
Allergic effects: Occasional urticaria, skin rash, etc., stop the administration once such effects spotted.
Circulation system: Occasional supraventricular arrhythmia and hypotension, once such symptom appears, decrease the amount or stop the administration.
Others: Occasional headache, fever, pain at the injection site, shock or thrombocytopenia.
Server adverse effects can be hemorrhagic cerebral infarction, extradural hemorrhage, encephalic hemorrhage, gastrointestinal hemorrhage, subcutaneous hemorrhage, etc.
CONTRADICTIONARIES:
The patients with following symptoms:
1. Allergic to ozagrel;
2. Cerebral hemorrhage or cerebral infarction with hemorrhage, deep coma accompanied large area cerebral infarction;
3. Severe impairment on heart, lung, liver, kidney, such as severe arrhythmia or cardiovascular infarction;
4. Hemopathy or hemorrhagic tendency;
5. Severe hypertension, with a contracting pressure of 200mmHg.
PRECAUTIONS:
Avoid mixing use of KADENIN and solution containing calcium (Green's solution) in case there will be white turbidity.
PREGNANCY AND LACTATION: Pregnant women should be administered with KADENIN with extreme care; Other usages haven't been found out yet.
GERIATRIC USE: Because of the low biological activity, the elder should be administered with KADENIN with extreme care.
DRUG INTERACTIONS: When used with platelet anti-coagulant, thrombosis dissolutant or other anti-coagulants, hemorrhagic tendency can be increased, therefore it should be used with extreme care. If necessary, the dose can be decreased.
OVERDOSAGE: Once the over-dosage happens, specific treatment should be granted to different symptoms, but the focus is to monitor the hemorrhage and coagulation and to deal with them promptly.
SPECIFICATIONS: 20mg (counted by ozagrel sodium C13H11N2NaO2)
STORAGE: Kept in dark with closure.
PACKAGING: Colorless glass tube for antibiotics
EXPIRATION PERIOD: 24 months
Beijing Kawin Bio-Tech Co., Ltd., also National Engineering Research Center for Viral Bio-Technology, was founded in 1999 with registered capital of USD20.43 million. Located in Beijing Economic-Technology Development Area (BDA), Kawin covers an area of 16, 000 square meters.
Beijing Kawin was applied by Ministry of Health and approved by State Planning Commission (current State Development and Planning Commission). We are National Engineering Research Center for Viral Bio-Technology (NERC-VBT) established as an enterprise with joint investment of State Development and Planning Commission and China Dalian International Cooperation (Group) Holdings Ltd. (CDIG). Our company is a duly subsidiary unit under Chinese Center for Disease Control and Prevention (CDC).
Beijing Kawin, with NERC-VBT as key institute, has been a pioneer in technological innovation field since our foundation. Led by well-known molecular biologist and academician Mr. Yunde HOU, NERC-VBT is full of talented people with doctor & master degrees. As a national research center, it undertakes several national "863" and "973" key research projects and represents the highest level of China in industrialized research. In 2002 Beijing Kawin was awarded as "National Key Project Enterprise".
At present, Beijing Kawin attaches great importance to our products. Relying on two fields of "Anti-virus" and "Brain nerves", our company currently has Human Recombinant Interferon series (prefilled syringe and vial injection) and several chemical products, such as omeprazole sodium for injection and ozagrel sodium for injection.
Beijing Kawin is aimed to become a specialized health service provider that provides all-round solutions, including products, technology and services. With Kawin people's Profession & Devotion, and by fully exerting the core advantage of being National Engineering Research Center for Viral Bio-Technology, Beijing Kawin is firmly moving ahead toward this goal. To achieve this goal, we welcome inquires and all kinds of cooperation from both domestic and abroad!
