Tinidazole Injection

Product name: Tinidazole injection
Main ingredients and chemical name: Tinidazole
Molecular formula: C8H13N3O4S
Molecular weight: 247.28

Character: The product is a colorless or almost colorless clear liquid.

Pharmacology and toxicity: The product has higher activity for protozoa and anaerobic bacteria, and has antibiosis activity for bacterides, clostridia, peptococcus, clostridium, peptostreptococcus, other bacillus, etc. The concentration of 2~4ml/l can restrain the majority anaerobic bacteria, microaerobe and helicobacter pylori are sensitive to this product; The MIC of trichomonas vaginalis is similar to metronidazole. Mechanism of action is not completely clarity. Nitroreductase of anaerobic bacteria has important effect in energy metabolism of sensitive strain, the nitro ic decomposed cytotoxic, thus affect metabolic of DNA, kill the anaerobic bacteria, drug-resistance bacteria have drug fast for this product. Because they are usually lack of nitroreductase, the function of this product through restaining the oxidation deoxidizing reaction of protozoa, it can rupture the azote bond of protozoa and kill it.

Pharmacokinetics: After administrated by intravenous drip 0.8g and 1.6g, the Cmax were 14-21mg/l and 32mg/l, administrated 1g by intravenous each day, Cmax can maintain 8mg/l above, tinidazole can widely scatter in every tissue organ in the body, it can achieve higher concentration in generative organ, intestinal tract, hind body, muscle, milk, lower concentration in liver, fat. The similar Cmax in bile, saliva to the corresponding time period, the penetrability is higer than metronidazole for blood-cerebrospinal fluid barrier. The concentration of cerebrospinal fluid is 80% of the corresponding time period when meninges has not inflammation. It has relationship with higher fatty of tinidazole. Tinidazole can achieve higher concentration in fetus, and placenta trough in liver, about 25%discharde from urine, the blood elimination beta was 11.6-13.3hour, average is 12.6hour.

Indications: Various anaerobic organisms infection: Septicemia, osteomyelitis, pelvic inflammation, peritoneum inflammation, lung infection, sinusitis, oral cavity inflammation, prevent infection after operation: Infection after colon and recta operation; Various anaerobic organisms infection etc after intestines operation and department of gynecology operation.

Geratology: Because pharmacokinetics and hypohepatia are changed, when the old man administrated, they should monitor blood concentration.

Pregnancy and lactation: The product can penetrate placenta, circulate immediately in fetus. Abdominal administration has toxicity for fetus in animal experiment, it has not enough and strictly contrast observation to the affection for fetus of human. The use is forbidden in lactation during 3 months, pregnant woman above 3 months are suggested to use the drug only appears significant symptom.

The concentration in milk is similar to in blood, it appears carcinogenesis to young rat. Women must avoid using it in lactation. If the drug must be used, lactation should be stopped a few days, and continue.

Specification: 100ml: 0.4g
Storage: Store in the closed container.
Package: Glass injection bottle
Expiry date: Two years