High quality Secnidazole CAS:3366-95-8
Product Name: alpha,2-Dimethyl-5-nitro-1H-imidazole-1-ethanol
Synonyms: SECNIDAZOLE;alpha,2-dimethyl-5-nitro-1h-imidazole-1-ethanol;SECNIDAZOLE, MM(CRM STANDARD);1-(2-Methyl-5-nitroimidazol-1-yl)-2-propanol;a,2-Dimethyl-5-nitro-1H-imidazole-1-ethanol;Flagentyl;PM 185184;RP 14539
CAS: 3366-95-8
MF: C7H11N3O3
MW: 185.18
EINECS: 222-134-0
Product Categories: Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API
Mol File: 3366-95-8.mol
Chemical Properties: Crystalline Solid
Usage: Analog of Metronidazole. Antiamebic. Antiprotozoal (Trichomonas)
Usage: antiameobic, antitrichomonas
Description:
Secnidazole belongs to category of antiprotozoal agents drugs. Secnidazole is a type of potentiate anticoagulant effect of warfarin. Concurrent disulfî Ram may cause antabuse-like effects cimetidine prolongs half-life.
It belongs to 5 nitroimidazole, effective in intestinal ameobiasis, giardiasis, trichomoniasis or bacterial vaginosis with a single once only dose.
Secnidazole is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. It has also been tested against Atopobium vaginae. This drug is commonly sold as Brand Name Flagentyl.
Applications:
Secnidazole has the advantage of being a single dose treatment and in humans treated with a single dose of secnidazole (30 mg/kg), it achieved up to 98% cure. Researchers, in a comparative study between secnidazole and metronidazole found a curative rate of 100% for secnidazole and 96% for metronidazole. However, when metronidazole was used in a single dose, its curative rate was reduced to 36-54%. On the other hand, a single dose of secnidazole reaches the same response achieved with multiple dosage regimens of metronidazole or tinidazole.
Side Effects of Secnidazole: Nausea, epigastric pain, glossitis, fatigue, head ache, loss of appetite, diarrhea stomatitis, urticaria rash & leucopenia.
Item | Specification |
| Appearance | Creamy white crystalline powder, having slight characteristic odor |
| UV Absorbance | 469-491 AT 391 nm |
Identification
A.Chemical reaction
B.UV
C.IR | A. Positive acid & alkaline chromogenic reaction
B. Max 319nm
C. Matches with standard |
| Melting Point | 70~76°C |
| Clarity of alcohol solution | 2%W/V in ethanol solution be clear |
| Solubility | Soluble in water,freely soluble in methanol ,
ethanol and glacial acetic acid,slightly soluble in ether |
| PH | 6.0~8.0 |
| Water content(KF) | 4.5%~6.5% |
| Residue on ignition | ≤ 0.1% |
| Heavy metals | ≤ 10ppm |
| Residual solvent | Ethyl acitate≤1000ppm |
| Related substances(HPLC) | 2-Methyl-5-nitro-imidazole≤0.5% |
| Any other individual impurity≤0.5% |
| Total impurities≤1.0% |
| Assay(HPLC) | ≥99.0% |
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