CJC-1295 with DAC
Pharmaceutical name: CJC-1295 with Drug Affinity Complex
Pack: 1 vial/2mg
CJC-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days. CJC-1295 is a Long acting GHRH analog. Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the hypothalamus by the arcuate nucleus. GHRH stimulates growth hormone (GH) secretion from the pituitary. GHRH is released in a pulsatile manner, stimulating pulsatile release of GH respectively. This substance also promotes slow wave sleep. The active portion of this GRF or GHRH peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment. Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection.
Wuhan Hezhong Bio-Chemical Manufacture Co., Ltd. belong to Yuancheng Group, a leading multifunctional enterprise in China, we specialize in Fine chemicals, pharmaceutical raw materials and intermediates...
The company invests large fund and brains to R&D department to research fine chemical, biochemical, pharmaceutical & its intermediates products that fit the demand of the market. High level research group, advanced apparatus and good scientific atmosphere ensure the quality of R&D. All the products in plant are the fruit of R&D department. Our products reach the advanced standard of domestic market, many of which reach the international standard.
The company capital asserts is above 100 million RMB. According to the GMP standard, the company has built 10000 m2 plant equipped the advanced equipment. The factory has a complete Q. A. & Q. C. system. We own several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and UV spectrophotometer to analyze and control the products. The company has gotten the approval of ISO9001. We have the authority of export and import, produced by the company and other fine chemical, biochemical, pharmaceutical & its intermediates distributed by the company are sold both in the domestic and international market and highly recommended by our clients. In order to develop the market further, we are eager to cooperate with the manufactory and trading company around the globe to make a prosperous future.
We advocate a enterprise idea that"people first, lead in the development of science and technology, serving society", insist on taking the road that"link science and technology as a marriage ", base on high-standard, new technologe, high quality. we have one batch the high-tech talent who are the chemical industry manages, produces,
develops, all kinds of professional and technical personnel's account for 30% of the total number of company, is devoted to research, development, production of the new high-tech product, introduce the products innovated constantly to the market. we own several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and UV spectrophotometer to analyze and control the products. The company has gotten the approval of ISO9001.
Our Staff will pursue high quality and perfect brand with untiring efforts, and inherit enterprising spirit on"candid, diligent, refinement, upwards", follow the enterprise management theory of"lives, services or soul of quality ", with the first-class products and high-quality service to meet market's demands.
Welcome to contact us!
