Steroid Hormone Clobetasol Propionate 99.5% Pharmaceuticals

Clobetasol Propionate
Alias:Dermovate
CAS No:25122-46-7
MF:C25H32ClFO5
MW:466.97
Purity:99% 
Package:1kg/aluminum foil bag
Appearance:Kind of white or light yellow crystalline powder. In choro form soluble in acetic acid, dissolved in the methanol and ethanol is soluble in water insoluble.
USES:Clobetasol propionate for synthetic efficient local external use sugar cortical hormone drugs. With strong anti-inflammatory, resistance to itch and capillary shrinkage effect, its anti-inflammatory effects of about 112.5 times of hydrocortisone sodium, betamethasone dipropionate ramification 2.3 times, fluocinolone 18.7 times. At the same time a suppression of mitosis Use, can effectively penetrate into skin cutin layer.
 
Certificate of Analysis
 
 

Product	Clobetasol Propionate
Batch Size	10.2kg	Mfg.Date	Dec 7, 2013
Report Date	Dec 7, 2013	Exp Date	Dec , 2015
Reference	USP35

 
 
 

Item	Specification	Result
Appearance	White to cream, crystalline powder	White crystalline powder
Identification (by IR)	Conforms to the CRS spectrum	Conforms
Melting Point	Approximately 196 °C	196°C
Specific rotation	+98°~+104°(dried substance)	+99.7°
Loss on drying	≤2.0%	0.2%
Residue on ignition	≤0.1%	0.06%
Heavy metals	≤20ppm	Conforms
Related substance (by HPLC)	Any impurity ≤1.0%	0.22%
	Total impurities ≤2.0%	0.31%
Assay(by HPLC)	Contains 97.0% to 102% of C25H32CIFO5 calculated on dried basis	99.9%
Residual solvents	Ethanol ≤3000ppm	262ppm
	Aceton ≤500ppm	Undetected(LOD 4ppm)
	Pyriding ≤100ppm	Undetected(LOD 3ppm)
	N,N-Dimethylformamide ≤100ppm	Undetected(LOD 10ppm)
Conclusion	Meet the specification according to USP35

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