Product Specifications
| Prod Model: |
CAS 69-65-8 |
| Markets: |
North America,South America,Eastern Europe,Southeast Asia,Africa,Oceania,Mid East,Eastern Asia,Western Europe |
| Product Name: |
Mannitol |
| CAS: |
69-65-8 |
| Einecs: |
200-711-8 |
| Molecular Formula: |
C6h14o6 |
| Molecular Weight: |
182.17 |
| Purity: |
99% |
| Appearance: |
White Powder |
| Grade: |
Pharmaceutical Grade |
Product Description
99% Pharmaceutical API Chemical Mannitol Diosmol Manna sugar
1.Basic Details
| Product Name | Mannitol |
| CAS NO. | 69-65-8 |
| Einecs No | 200-711-8 |
| Molecular formula | C6H14O6 |
| Molecular weight | 182.17 |
| Purity | 99% |
| Grade | Pharmaceutical Grade |
| Appearance | White Powder |
| Usage | diuretic,reducing intracranial pressure |
2.Description
Mannitol (also referred to as mannite or manna sugar) is a white, crystalline solid that looks and tastes sweet like sucrose. It was originally isolated from the secretions of the flowering ash and called manna after its resemblance to the Biblical food. In plants it is used to alleviate osmotic stress. Mannitol has several industrial uses, but is mainly used to produce tablets of medicine. Mannitol is classified as a sugar alcohol; that is, it is derived from a sugar (mannose) by reduction. Other sugar alcohols include xylitol and sorbitol. Mannitol and sorbitol are isomers, the only difference being the orientation of the hydroxyl group on carbon 2.
3.Application
Mannitol is used clinically in osmotherapy to reduce acutely raised intracranial pressure until more definitive treatment can be applied, e.g., after head trauma. It is also used to treat patients with oliguric renal failure. Intravenous mannitol opens the blood-brain barrier to hydrophilics by stretching the tight junctions between the endothelial cells.
Mannitol is commonly used in the circuit prime of a heart lung machine during cardiopulmonary bypass. The presence of mannitol preserves renal function during the times of low blood flow and pressure, while the patient is on bypass. The solution prevents the swelling of endothelial cells in the kidney, which may have otherwise reduced blood flow to this area and resulted in cell damage.
Mannitol is also the first drug of choice for the treatment of acute glaucoma in veterinary medicine. It is administered as a 20% solution IV. It dehydrates the vitreous humor and, therefore, lowers the intraocular pressure. However, it requires an intact blood-ocular barrier to work.
Mannitol can also be used to temporarily encapsulate a sharp object (such as a helix on a lead for an artificial pacemaker) while it is passed through the venous system. Because the mannitol dissolves readily in blood, the sharp point will become exposed at its destination.
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