Moxifloxacin hydrochloride
Product name: Moxifloxacin hydrochloride
Other name: AVALOX; BAY-12-8039; ACTIRA; PROFLOX; MOXIFLOXACIN HCl
CAS No.: 186826-86-8
Assay: 99%
Packing: 1kg/tin; 25kg/drum
M. F.: C21H25ClFN3O4
M. W.: 437.89
Appearance: Light yellow powder
Introduction:
Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent developed by Bayer AG (initially called BAY 12-8039). It is marketed worldwide (as the hydrochloride) under the brand names Avelox, Avalox, and Avelon for oral treatment. In most countries, the drug is also available in parenteral form for intravenous infusion. Moxifloxacin is also sold in an ophthalmic solution (eye drops) under the brand names Vigamox, and Moxeza for the treatment of conjunctivitis (pink eye). Its antibacterial spectrum includes enteric Gram-() rods (Escherichia coli, Proteus species, Klebsiella species), Haemophilus influenzae, atypical bacteria (Mycoplasma, Chlamydia, Legionella), and Streptococcus pneumoniae, and anaerobic bacteria. It differs from earlier antibacterials of the fluoroquinolone class such as levofloxacin and ciprofloxacin in having greater activity against Gram-positive bacteria and anaerobes. Because of its potent activity against the common respiratory pathogen Streptococcus pneumoniae, it is considered a "respiratory quinolone."
Uses:
Moxifloxacin is used to treat a number of infections, including: respiratory tract infections, cellulitis, anthrax, intraabdominal infections, endocarditis, meningitis, and tuberculosis.
Analysis Test | Specification | Result |
| Description | crystalline powder | Conforms |
| Solubility | soluble in water | Conforms |
| PH | 6.0~7.5 | 6.9 |
| Solution clarity and color | solution should be clear and colorless | Conforms |
| Related substances | 5'CMP 0.3%
Simple impurity
Total other impurity | 0.01%
0.03%
0.10% |
| Chloride | 0.05% | Conforms |
| Ammonium | 0.05% | Conforms |
| Fe | 0.01% | Conforms |
| Phosphate | 0.1% | Conforms |
| Loss on drying | ≤6.0% | 1.3% |
| Heavy metals | 0.002% | Conforms |
| Arsenide | 0.0001% | Conforms |
| Bacterial Endotoxins | 0.3EU/mg | Conforms |
| Microbial Limit | Conforms | Conforms |
| Assay(on dried basis) | ≥98.0% | 98.8% |
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