yellow pigment Artemisinin Pharmaceutical Intermediates
Quick detail;
English name: Artemisinin
Chinese alias: Artemisia annua, yellow pigment, yellow artemisinin
99% HPLC CP2010
English Name: Arteannuin, Artemisinine, Qinghaosu
Molecular formula: C15H22O5
Molecular Weight: 282.33
Colorless needle-like crystals, bitter taste.
In propionate \ ketone, ethyl acetate, chloroform, benzene and glacial acetic \ acid soluble in ethanol and methanol, ethanol \ ether and petroleum ether soluble, almost insoluble in water.
Melting point: 156-157 ºC (decomposition after decoction)
description;
Artemisinin is rapidly absorbed from the gut after oral administration, 0.5 to 1 hour after the peak plasma concentration, decreased by half after four hours, 72 hours only a trace of blood. Its concentration in red blood cells is lower than plasma concentrations. After absorption and distribution in the tissue to the intestine, liver and kidney are more content. The product is fat-soluble substance, it can enter the brain through the blood-brain barrier. Quickly metabolized in the body, structure and properties of metabolites unclear. Mainly from the kidney and intestinal tract, can discharge 84% 24 hours, 72 hours only a small amount of residual. Since the metabolism and excretion are fast, effective blood concentration of short duration, is not conducive to completely kill the malaria parasite, so the higher recurrence rate. Artemisinin derivative artesunate, T1 / 2 was 0.5 hours, it should be repeated doses.
Application;
1. Mainly used for vivax malaria, falciparum malaria symptom control, and treatment of chloroquine-resistant insect strains, it can also be used to treat dangerous type of malignant malaria, such as cerebral, jaundice, and so on. Also for the treatment of systemic lupus erythematosus and discoid lupus erythematosus.
2. artemisinin low toxicity, safe to use, generally no significant adverse reactions. Few cases, loss of appetite, nausea, vomiting, diarrhea and other gastrointestinal reactions, but not serious. Aqueous suspensions of mild irritation at the injection site. Individuals a transient increase in transaminases, mild rash. Few people have nausea, vomiting, diarrhea, self-healing
Product Name Artemisinin annua extract
Storage sealed, placed in a cool, dry environment, avoid moisture, light, heat.
Specifications:
| Product name | Artemisinin |
| Alias | Artemisinin |
| CAS; | 564-20-5 |
| Molecular weight; | 282.33 |
| Formula; | C15H22O5 |
| Application forms | yellow pigment |
| Colorless | bitter taste |
| Melting point: | 156-157 ºC |
| Loss on drying: | Less than 0.5% |
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